https://www.mayoclinic.org/diseases-conditions/osteoporosis/in-depth/osteoporosis-treatment/art-20046869, https://connect.mayoclinic.org/discussion/reclast-infusion/, https://americanbonehealth.org/bonesense/why-strontium-is-not-good-for-bone-health/. 9-1-2005;30(17 Suppl):S84-S91. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician, https://www.ema.europa.eu/en/news/prac-recommends-suspending-use-protelososseor, https://theros.org.uk/latest-news/2019-01-14-strontium-ranelate-returns-to-the-uk-as-an-osteoporosis-drug-treatment. A common therapeutic dose you will often seen recommended for boosting bone health is 680 milligrams per day. 2012;23(1):295-303. doi: 10.1007/s00198-011-1547-8. J Am Diet Assoc 1987;87:1644-50. View abstract. View abstract. B., Eriksen, E. F., Ish-Shalom, S., Genant, H. K., Wang, O., and Mitlak, B. H. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. View abstract. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Lancet 12-7-1996;348(9041):1535-1541. Lets take a look at the possible health benefits of strontium. Reginster, J. Y., Felsenberg, D., Boonen, S., Diez-Perez, A., Rizzoli, R., Brandi, M. L., Spector, T. D., Brixen, K., Goemaere, S., Cormier, C., Balogh, A., Delmas, P. D., and Meunier, P. J. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. A., Thompson, D. E., Nevitt, M. C., Bauer, D. C., Genant, H. K., Haskell, W. L., Marcus, R., Ott, S. M., Torner, J. C., Quandt, S. A., Reiss, T. F., and Ensrud, K. E. Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Adouble-blind, parallel, comparative study study published back in 1987 in the Journal of Periodontology looked at the effects of a toothpaste containing10 percent strontium chloride hexahydrateon 61 subjects with hypersensitivity. Quintessence.Int. Clin Nucl Med 2004;29:81-5. (23), In general, taking very high doses of a Sr supplement is typically not considered safe and taking too much could even damage bones, so be careful when taking strontium, as recommended by the ATSDR (Agency for Toxic Substances and Disease Registry). Reginster, J. Y., Seeman, E., De Vernejoul, M. C., Adami, S., Compston, J., Phenekos, C., Devogelaer, J. P., Curiel, M. D., Sawicki, A., Goemaere, S., Sorensen, O. H., Felsenberg, D., and Meunier, P. J. Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study. I now take 680 mg strontium citrate without side effects and the fractures have stopped. Strontium has a long list of undesirable side-effects, commonly ranging from nausea to skin irritation, and less often (fortunately), blood clots and fainting. strontium is unlikely to have a net beneficial effect in osteoporosis and its use is declining as a consequence. Arrich, J., Piribauer, F., Mad, P., Schmid, D., Klaushofer, K., and Mullner, M. Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis. View abstract. Many formulas for bone health will include a form of Sr. It's not known if strontium contained in dietary supplements has these effects. Kidney Int 2003;64:534-43. . View abstract. View abstract. 1992;63(1):7-12. Seeman E, Boonen S, Borgstrm F, et al. The possible risks of strontium warrant more long-term independent studies. Radiother Oncol 1994;31:33-40. are clickable links to these studies. So what is stable strontium exactly? BORON: Overview, Uses, Side Effects, Precautions, Interactions - WebMD View abstract. View abstract. Available at: https://www.fda.gov/cder/ogd/approvals/1stgen0103.htm. Can Med Assoc J 1981;125:703-12.. View abstract. The compound Strontium Citrate has CAS number 40182-75- and molecular formula C6H5O7Sr-. J.Periodontol. Hahn, G. S. Strontium is a potent and selective inhibitor of sensory irritation. Strontium: Facts, Health Benefits and Dosage - BitterMelon A double-blind, randomized placebo-controlled trial published in The Journal of Clinical Endocrinology and Metabolism looked at the effects of Sr on 261 men with primary osteoporosis. STRONTIUM - Uses, Side Effects, and More - WebMD View abstract. 2013 Feb;98(2):592-601. doi: 10.1210/jc.2012-3048. It's also known to increase osteoprotegerin that serves as the decoy for the RANKL and slows the rate of bone resorption. Esomeprazole (Nexium) is not the same medication as esomeprazole strontium, although both are used to treat similar stomach conditions. 1998;4(2):114-119. Boron has been consumed for menstrual cramps and boric acid has been used vaginally for yeast infections, but evidence is limited. Bellamy, N., Campbell, J., Robinson, V., Gee, T., Bourne, R., and Wells, G. Viscosupplementation for the treatment of osteoarthritis of the knee. However, Sr-89 (a radioactive form) is considered to be unsafe for pregnant and breast-feeding women. Protelos European Summary of Product Characteristics. View abstract. Results of Russian multicenter trial]. Hernandez, F., Mohammed, C., Shannon, I., Volpe, A., and King, W. Clinical study evaluating the desensitizing effect and duration of two commercially available dentifrices. Best Joint Supplements In 2023: Knee Pain & Joint Support. A double blind, prospective, placebo-controlled study. 2004;86-A(3):538-545. Ann.Rheum.Dis. Omdahl JL, DeLuca HF. I just read this article about strontium. Meunier, P. J., Roux, C., Ortolani, S., Diaz-Curiel, M., Compston, J., Marquis, P., Cormier, C., Isaia, G., Badurski, J., Wark, J. D., Collette, J., and Reginster, J. Y. View abstract. Strontium-89 chloride in the treatment of bone metastases from breast cancer. View abstract. Anastasilakis, A. D., Polyzos, S. A., Avramidis, A., Papatheodorou, A., and Terpos, E. Effect of strontium ranelate on lumbar spine bone mineral density in women with established osteoporosis previously treated with teriparatide. OTHER NAME(S): Atomic number 38, Chlorure de Strontium, Chlorure, Strontium is a silvery metal found naturally as a non-radioactive element. Bone 2006;38(2 Suppl 1):23-27. Also, the FDA doesnt regulate supplements in the same way as prescription drugs, so it's not possible to know if if they are safe or work well or even how much of the main ingredient they contain. View abstract. 1978;57(9-10):903. Sairanen S, Karkkainen M, Tahtela R, et al. BMC.Musculoskelet.Disord. Strontium Citrate Demonstrates its Safety and Effectiveness Stable strontiums atomic symbol is Sr, its atomic number is 38 and its atomic weight is 87.62. Ettinger, B., Black, D. M., Mitlak, B. H., Knickerbocker, R. K., Nickelsen, T., Genant, H. K., Christiansen, C., Delmas, P. D., Zanchetta, J. R., Stakkestad, J., Gluer, C. C., Krueger, K., Cohen, F. J., Eckert, S., Ensrud, K. E., Avioli, L. V., Lips, P., and Cummings, S. R. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Male hormones (Androgens) might decrease how fast the body gets rid of strontium. (2). J.Dent.Res. Reginster, J. Y. and Meunier, P. J. Strontium ranelate phase 2 dose-ranging studies: PREVOS and STRATOS studies. Br.J.Clin.Pharmacol. Strontium can be found in supplement form online and in health stores. View abstract. Theres not enough research to know if strontium fights osteoporosis. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis--a 2-year randomized placebo controlled trial. Use strontium supplements with caution if you have kidney disease. 99% of the strontium found in the human body is in the bone. It can be found in soil and seawater, and its actually used as a supplemental treatment for osteoporosis and other bone diseases. View abstract. J.Dent.Res. Interaction of strontium and vitamin D. C R Seances Soc Biol Fil 1975;169:322-9. Pearce, E. I. and Sissons, C. H. The concomitant deposition of strontium and fluoride in dental plaque. Seeman, E., Vellas, B., Benhamou, C., Aquino, J. P., Semler, J., Kaufman, J. M., Hoszowski, K., Varela, A. R., Fiore, C., Brixen, K., Reginster, J. Y., and Boonen, S. Strontium ranelate reduces the risk of vertebral and nonvertebral fractures in women eighty years of age and older. Dose-dependent effects of strontium on osteoblast function and mineralization. To avoid this interaction, take strontium at least 2 hours before or after taking quinolones. 2013 Feb;72(2):179-86. doi: 10.1136/annrheumdis-2012-202231. View abstract. Rheumatol.Int. Strontium ranelate has also been linked with a small increase in blood clot risk so it should not be taken by anyone with a blood clotting disorder. It is said to have first been found in the ores of lead mines in Strontian in 1787. Arthritis Rheum. 2007;5(4):692-699. Strontium results in an overestimation (up to 50%) of the increase in bone density using DXA methods.[3]. 2000;83(5):657-660. Osteoporos.Int. View abstract. A phase III study of the effects of denosumab on vertebral, nonvertebral, and hip fracture in women with osteoporosis: results from the FREEDOM trial [Abstract 1286]. Strontium Ranelate returns to the UK as an osteoporosis drug treatment. 2019, As a service to our readers, American Bone Health provides access to our library of archived content. Perit Dial Int 1998;18:410-4. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group. How Well are You Living With Ankylosing Spondylitis? View abstract. Boron: Benefits, Side Effects, Dosage, and Interactions - Verywell Health If youre not into chemistry, then those scientific facts probably dont mean that much to you. Scientific studies have shown that Sr may have positive effects on bone diseases like osteoporosis, bone cancer, prostate cancer, tooth sensitivity and tooth decay. Spector, T. D., Conaghan, P. G., Buckland-Wright, J. C., Garnero, P., Cline, G. A., Beary, J. F., Valent, D. J., and Meyer, J. M. Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]. (. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. 2005 - 2023 WebMD LLC. Strontium Citrate side effects - Osteoporosis - Inspire 2004;5(7):1635-1638. Doctors can prescribe it only for postmenopausal women and for men with severe osteoporosis who cant take other drugs. Strontium Uses, Potential Benefits, Risks and Side Effects - Dr. Axe Ngo, H. C., Mount, G., Mc, Intyre J., Tuisuva, J., and Von Doussa, R. J. Clinically meaningful effect of strontium ranelate on symptoms in knee osteoarthritis: a responder analysis. [No authors listed]. J Bone Miner Res 2001;16:299-308. . @faith123, recently posted about having a second reclast infusion recently here, https://connect.mayoclinic.org/discussion/reclast-infusion/. View abstract. The product can increase bone density, and it can also slow down bone loss. 2006;21(7):1113-1120. Further research is still needed and it can be dangerous to use these supplements if you have certain health conditions. However, I dont advocate using these supplements without first reviewing the precautions listed below and talking with your health care provider. Study design: Prospective animal model study. On October 1, 2014 the European Medicines Agencys Pharmacovigilance Risk Assessment Committee (PRAC) recommended that strontium ranelate (Protelos/Osseor, Servier) no longer be used to treat osteoporosis because of data demonstrating serious negative side effects. 5 Reasons to Add Lamb Meat to Your Diet. AlgaeCal Plus Reviews - Is it safe for bone health? Strontium for Treating Osteoporosis and for Bone Health - WebMD Oosterhof GO, Roberts JT, de Reijke TM, et al. Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others. Uchida, A., Wakano, Y., Fukuyama, O., Miki, T., Iwayama, Y., and Okada, H. Controlled clinical evaluation of a 10% strontium chloride dentifrice in treatment of dentin hypersensitivity following periodontal surgery. Several different forms of strontium are used as medicine and strontium chloride is the most common form of strontium found in. [RETRACTED]. [4] Simpson, Lani. Arch.Intern.Med. Kidney Int. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Contact Dermatitis 2000;42(2):98-100. Founded in 1999, ConsumerLab.com is a leading provider of consumer information and independent evaluations of products that affect health and nutrition. View abstract. 1984;55(12):720-725. Mazor, Z., Brayer, L., Friedman, M., and Steinberg, D. Topical varnish containing strontium in a sustained-release device as treatment for dentin hypersensitivity. Note that the numbers in parentheses (1, 2, etc.) Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. The forms of strontium available over-the-counter in the U.S. or on the Internet are usually strontium citrate or strontium chloride. Do not take it within 2 hours of ingesting calcium so I take it at bedtime. Effects of oral supplementation with stable strontium. I am fortunate to have no noticeable side effects. Positive impact of compliance to strontium ranelate on the risk of nonvertebral osteoporotic fractures. View abstract. My teeth are really strong and it feels like my bones are too. It also appears that people with strontium in their local water supply seem to have decreased cavity risk. N Engl J Med 2004;350:504-6. The objective of this study was to determine whether strontium citrate can be used to enhance bone healing during MDO in a rabbit model. J.Periodontol. Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity. Maheu E, Mazieres B, Valat JP, et al. @kishanvasekar My girlfriend has osteoporosis and the Dr put her on high doses of Vit D-3 sunshine exercise especially weights ,swimming .She is doing good. Ann Rheum Dis. Rheumatology (Oxford). Can and should treatments such as these be used in conjunction with strontium citrate, about which I know nothing by the way? Pennington JA, Jones JW. If you want to take a strontium supplement, ask your doctor first. View abstract. Delayed strontium absorption in post-menopausal osteoporosis and osteomalacia. Some tetracycline antibiotics include demeclocycline (Declomycin), minocycline (Minocin), and tetracycline. View abstract. View abstract. An extensive scientific review published in 2000 concludes that: It is clear from published reports and from daily practice that injection with Sr-89 is a simple, well-tolerated treatment providing a considerable chance of good palliation of pain in patients with bone metastases from prostate cancer. Krachler, M., Domej, W., and Irgolic, K. J. It can be found in soil and seawater as well as some foods. Performance Lab Flex - Best For Athletes. Some years later in 1808, it was was isolated in its metallic formusing electrolysisby Sir Humphry Davy at the Royal Institution in London. Overall, the results of this 2013 study performed with male subjects demonstrated that strontium ranelate supplementation appears to improve bone mineral density in men similar to the way it has been shown to help postmenopausal women struggling with osteoporosis. View abstract. Connect with thousands of patients and caregivers for support, practical information, and answers. Strontium ranelate discontinued. View abstract. Nonvertebral fracture benefit from oral ibandronate administered daily or with a unique drug-free interval: Results from a pivotal phase III study in postmenopausal osteoporosis (PMO). Strontium as a marker for intestinal calcium absorption: the stimulatory effect of calcitriol. Because strontium atoms are heavier than calcium atoms, swapping some of the calcium atoms with strontium atoms will make the bone mineral density appear to increase. I feel that I need something that is shown to rebuild bone (15 lumbar and thoracic vertebral compression fractures). View abstract. 1994;65(2):113-119. View abstract. Increased serum strontium levels in dialysis patients: an epidemiological survey. Strontium(89) chloride versus palliative local field radiotherapy in patients with hormonal escaped prostate cancer: a phase III study of the European Organisation for Research and Treatment of Cancer, Genitourinary Group. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. View abstract. Thromb.Haemost. Natural strontium has a silvery white metallic color with a tint of yellow. Afflitto, J., Schmid, R., Esposito, A., Toddywala, R., and Gaffar, A. Fluoride availability in human saliva after dentifrice use: correlation with anticaries effects in rats. A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentin hypersensitivity. It may even cause constipation or digestive discomfort. J.Periodontol. J.Bone Miner.Res. Dermatology 2000;200(3):244-246. 1992;71 Spec No:841-845. Sr-89 has been used as a form of treatment to manage pain resulting from bone pain due to cancer. Review of clinical studies. J Endod 2002;28:34-5. A number of studies have shown that it can strengthen bone and reduce the risk of fractures, even among women 74 years of age or older when risks are highest. A., Weiss, S. R., Broll, J., Minne, H. W., Quan, H., Bell, N. H., Rodriguez-Portales, J., Downs, R. W., Jr., Dequeker, J., and Favus, M. Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. Strontium may also influence other essential functions, including calcium absorption, bone formation & breakdown, and it restores alkaline pH to improve the health of skin, hair, and nails). O'Donnell, S., Cranney, A., Wells, G. A., Adachi, J. D., and Reginster, J. Y. Strontium ranelate for preventing and treating postmenopausal osteoporosis. Robinson, R. G., Spicer, J. Oncology 1998;55:377-81. View abstract. The radioactive form of Sr is not available as a dietary supplement, but it is considered to likely be safe when administered by a health care professional by IV. View abstract. The PRAC weighed the benefits of the medicine against the known risks and concluded that the balance was no longer favourable and recommended Protelos/Osseor be suspended until there are new data showing a favourable balance in a defined patient group.[1]. J.Clin.Periodontol. Gillam, D. G., Newman, H. N., and Bulman, J. S. The effect of strontium chloride hexahydrate dentifrices on plaque accumulation and gingival inflammation. 2012. Silverstein, M. D., Heit, J. View abstract. Note that the numbers in parentheses (1, 2, etc.) Robinson RG, Preston DF, Schiefelbein M, Baxter KG. This technology we use to assemble our list depends on a variety of factors, including but not limited to the following: Brand Value: Every brand of strontium citrate . Because strontium and calcium have very similar molecular structures, the body treats them much the same. Strontium citrate side effects? - Osteoporosis - Inspire Low . 2006;34(8):608-613. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Research shows that a special prescription form of strontium (strontium-89 chloride) given intravenously (by IV) reduces pain from metastatic, Weak and brittle bones (osteoporosis). Generic drug List. N.Engl.J.Med. View abstract. This is not the same as making new bone. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. 2006;54(10):3205-3211. Osteoporos.Int. J Periodontol. I wont name names, but some of the most well-known toothpastes for sensitive teeth include strontium in their formulas. Environ Sci Pollut Res Int 2021;28(18):23048-23059. Disease-modifying effect of strontium ranelate in a subset of patients from the Phase III knee osteoarthritis study SEKOIA using quantitative MRI: reduction in bone marrow lesions protects against cartilage loss. Dahl SG, Allain P, Marie PJ, et al. Johnson, G. H., Bales, D. J., Gordon, G. E., and Powell, L. V. Clinical performance of posterior composite resin restorations. American Bone Health4208 Six Forks RoadSuite 1000Raleigh, NC 27609. Efficacy and safety of strontium ranelate in the treatment of osteoporosis in men. Possible side effects of radioactive Sr (Metastron) as a bone cancer treatment may include: (22). Although many people have never heard of it before, its a very interesting and somewhat controversial supplement. I was diagnosed with osteopenia", "I have osteoporosis and am afraid of the treatments for it have been trying strontium citrate", "My wife has severe Osteoporosis .It has been improving with Medicines, Yearly injections , Exercise ,". Icelandic Red Algae Calcium - Best For Seniors. This could cause the body to have too much strontium and potentially cause side effects. Les Laboratoires Servier ceased the distribution of Protelos/Osseor in August 2017. If you are concerned about the bone-thinning disease osteoporosis, you may have heard about treatment with strontium. A prescription form of strontiumstrontium ranelate (the ranelate salt), known as Protelos/Osseor was authorized in the European Union to treat severe osteoporosis in women who have been through the menopause and men who are at high risk of broken bones or fracture in the spine and the hip. Rheumatol.Int. [Efficacy and safety of bivalos therapy for postmenopausal osteoporosis. Best Joint Supplements 2023: Top 3 Products Review & Compare Is Lamb Healthy? My Dr wants me to start taking this. Can Strontium Boost Bone Health And Prevent Osteoporosis? Reginster, J. Y., Lecart, M. P., Deroisy, R., and Lousberg, C. Strontium ranelate: a new paradigm in the treatment of osteoporosis. Oral Dis. Symptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. Fracture Intervention Trial Research Group. FreshSplash/Getty Images. Am J Med 1993;95:69S-74S. It is prescribed only for those who would otherwise have no other suitable treatment to reduce their risk of broken bones.[2]. Strontium is a mineral and alkaline earth metal like calcium, and it seems to work similarly to calcium in the body with its main benefit being a boost to bone health. What you need to know about strontium suppements for osteoporosis. JAMA 12-23-1998;280(24):2077-2082. View abstract. Bone mass and markers of bone and calcium metabolism in postmenopausal women treated with 1,25-dihydroxyvitamin D (Calcitrol) for four years. JAMA 12-17-2003;290(23):3115-3121. A., Johansson, H., Oden, A., and McCloskey, E. V. A meta-analysis of the effect of strontium ranelate on the risk of vertebral and non-vertebral fracture in postmenopausal osteoporosis and the interaction with FRAX((R)). J Rheumatol 2000;27:205-11. That means it may affect how strong your bones are. Please note the date of the last review on all articles. Agency for Toxic Substances and Disease Registry. In the human body, approximately 99 percent of Sr is located in the bones. Accessed May 1, 2018. Protos [Product Information]. Center for drug evaluation and research. View abstract. Am J Med. Strontium citrate and strontium chloride are supplements and are not tested or regulated by the Food and Drug Administrations (FDA). Type: Natural Calcium & Magnesium Supplement. Dermatol.Surg. Ananthraman, J. and Shahani, S. N. Clinical management of dentin hypersensitivity using cathode and anode iontophoresis. Pelletier JP, Roubille C, Raynauld JP, et al. After a 7-day . Form: Capsules. The drug makes your bones stronger and lowers your chances of getting fractures. Hello @bonelady. Glucosamine therapy for treating osteoarthritis. (17), In the 19th century, the first large scale use of strontium took place when it was employed to extract the sugar from sugar beets. Rizzoli R, Chapurlat RD, Laroche JM, et al. (16), Strontiums name comes from Strontian, a village in Scotland. Why Strontium Is Not Advised for Bone Health Since strontium is denser than calcium, it is difficult to assess actual bone improvement in a DXA scan. If side effects are persistent or worsen, it is best to talk to your healthcare provider. 2010;46(4):1038-1042. doi: 10.1016/j.bone.2009.12.006. (3). Strontium absorption also has effects on the absorption ofcalcium, magnesium and phosphate ions. View abstract. 2008;83(5):308-314. Bone 2001;28:446-53. Reginster, J. Y., Deroisy, R., Dougados, M., Jupsin, I., Colette, J., and Roux, C. Prevention of early postmenopausal bone loss by strontium ranelate: the randomized, two-year, double-masked, dose-ranging, placebo-controlled PREVOS trial. El-Hajj Fuleihan G. Strontium ranelate--a novel therapy for osteoporosis or a permutation of the same? Osteoporos.Int. More Information Middleton ET, Steel SA, Aye M, Doherty SM. Ter.Arkh. J Clin Endocrinol Metab 2002;87:2060-6.. View abstract. The typical diet includes 0.5 to 1.5 milligrams of strontium each day. J Bone Miner Res 2008;23(S80). Apostolidis N, Paradellis T, Karydas A, et al. View abstract. 2007;18(12):1617-1624. 1980;51(10):578-581. For two years, 174 of the men received 2 grams of strontium ranelate per day while 87 men received a placebo. The effect of fluoride and strontium application on dentin: in vivo and in vitro studies. View abstract. Injecting myself daily. In general, there is not enough research to determine if any form of Sr is safe for pregnant and nursing moms so its best not to use these supplements under these circumstances.